Utilizing single-molecule optical and AFM imaging and drive-spectroscopy approaches, we seek out to unravel the mechanistic elements of the structure and dynamics of chromosomes. Our investigate pursuits include things like:
Human Rad51 filaments on double- and single-stranded DNA: correlating common and irregular forms with recombination operate.
Round the identical time, the team of Paul McEuen, who was then dependent with the University of California, Berkeley, confirmed equivalent outcomes on ropes of bundled nanotubes. Depending on the wrapping angle, nanotubes can can be found in metallic or semiconducting variants, a prediction that we and Charles Lieber’s group at Harvard College independently confirmed using scanning tunnelling spectroscopy experiments.
Deposition and atomic force microscopy of individual phthalocyanine polymers between nanofabricated electrodes
Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond intelligent style in 2005. (nl)
Immediate immobilization of native yeast iso-1 cytochrome c on bare gold: fast electron relay to redox enzymes and zeptomole protein-movie voltammetry
What distinguishes biology from chemistry is always that these components jointly make up a living technique. The secret of claimed lifestyle, I do think, lies within the interactions, the interaction of These molecules. The large issue about the origin of daily life remains unanswered. How did we ever evolve from uncomplicated molecules into the really complex programs we see today? We don't know. I would like to operate on these kinds of massive, open up concerns.’
Studying DNA loop extrusion by SMC proteins for chromosome architecture with solitary-molecule assays.
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one). The current–voltage curves confirmed significant modulations with gate voltage, even at place temperature, which was in step with band bending inside of a ~0.6 eV bandgap semiconducting nanotube. These facts also showed the conductance could be modulated by six orders of magnitude by switching the gate voltage. The outcome of the function — a place-temperature transistor made from an individual https://www.ceesdekker.net carbon nanotube molecule — were being revealed in Mother nature in Could 1998.
[fourteen] In 2005 Dekker grew to become linked to Netherlands-vast conversations about Intelligent Layout, a motion that he has given that Evidently distanced himself from. Dekker advocates that science and religion will not be in opposition but can be harmonized.
Numerous new phenomena were being uncovered, and he and his study team set up a number one place During this discipline of research. Dekker and his exploration group learned new physics of nanotubes in addition to explored the feasibility of molecular electronics. In 1998, they were being the initial to make a transistor determined by a single nanotube molecule.
2005, discovery on the mechanism of DNA uncoiling by topoisomerase enzymes; discovery of very long-array conformational improvements in Mre11/DNA restore complexes; and initially force measurements over a DNA molecule in a nanopore
Strong-state nanopores have confirmed to become a astonishingly adaptable probe for single-molecule Evaluation of DNA. I will explain many of our the latest conclusions – specially DNA knots – and our endeavours to develop the abilities of sound-state nanopores even additional, within the direction of one-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.